VIB is inviting applications for a PhD position in mRNA Vaccination and Innate Immunity at the Nucleic Acid Immunity Lab, part of the VIB-UGent Center for Inflammation Research in Ghent, Belgium. This opportunity is ideal for graduates interested in immunology, molecular biology, biotechnology, and vaccine research who wish to contribute to understanding how mRNA vaccines activate protective immune responses.
The successful candidate will join an internationally recognized research team investigating the role of nucleic acid sensing pathways in vaccine-induced immunity. The project combines molecular cell biology, immunology, and in vivo experimentation to uncover the mechanisms that drive effective immune protection following mRNA vaccination.
| Category | Details |
|---|---|
| Location | Ghent, Belgium |
| Application Deadline | 17 July 2026 |
| Discipline | Life Science |
| Qualification Required | Master’s Degree or Equivalent |
| Duration | Initial 1-year scholarship, renewable for 3 additional years |
Overview of the PhD Position
Nucleic acids play a central role in immune defense by activating intracellular sensors that detect viral RNA and DNA. These sensing mechanisms initiate antiviral responses that help protect the host against infection. Beyond their role in infectious diseases, nucleic acid sensing pathways have become increasingly important in modern vaccine technologies, particularly mRNA vaccines.
This PhD project aims to identify the nucleic acid sensors responsible for inducing protective immunity following mRNA vaccination. The research will contribute to a broader understanding of how vaccine-derived RNA molecules interact with the immune system and how these interactions influence vaccine efficacy.
The project forms part of a collaborative research effort involving the laboratories of Sophie Janssens and Stefaan De Smedt, bringing together expertise from immunology, pharmaceutical sciences, and molecular biology to study the mechanisms underlying mRNA vaccine responses.
Research Areas and Focus
| Area | Focus |
|---|---|
| mRNA Vaccination | Investigating how mRNA vaccines stimulate protective immune responses. |
| Innate Immunity | Understanding the immune pathways activated by viral and vaccine-derived nucleic acids. |
| Nucleic Acid Sensing | Identifying sensors responsible for detecting RNA molecules and triggering immunity. |
| Molecular Cell Biology | Exploring cellular mechanisms involved in immune activation and signaling. |
| In Vivo Vaccination Models | Using mouse models to study immune responses following mRNA vaccination. |
What the Programme Offers
Successful candidates will benefit from:
- A fully funded doctoral scholarship
- Initial one-year appointment with the possibility of renewal for three additional years following positive evaluation
- Access to state-of-the-art research facilities and advanced technologies
- Training in molecular cell biology, immunology, and vaccine research
- Opportunities for networking, mentorship, and professional development
- Support for applying to competitive personal fellowships such as FWO PhD fellowships
- A collaborative and international research environment
- Direct involvement in cutting-edge research related to mRNA vaccines and immune regulation
Eligibility Requirements
Applicants should possess:
- A Master’s degree in Biochemistry, Molecular Biology, Cell Biology, Biotechnology, Biomedical Sciences, Bioengineering, or a related discipline
- Strong interest in immunology and fundamental biological research
- Excellent communication skills and proficiency in English
- Ability to work independently and as part of an international research team
- Attention to detail and strong motivation for scientific research
- Willingness to obtain a FELASA C license for animal experimentation if required
Selection Process
Applications will be assessed based on:
- Academic qualifications and scientific background
- Research experience and technical expertise
- Motivation and suitability for the project
- Communication skills and ability to work in a collaborative environment
- Alignment of previous training with the objectives of the research programme
Shortlisted candidates will be invited for interviews before final selection.
Why Join VIB?
VIB is one of Europe’s leading life science research institutes, recognized internationally for excellence in biotechnology, immunology, molecular biology, and biomedical research. Researchers at VIB work in highly collaborative environments equipped with modern research infrastructure and supported by strong academic partnerships.
The Nucleic Acid Immunity Lab provides an outstanding environment for doctoral training, offering access to internationally recognized expertise in inflammation research, innate immunity, and vaccine biology. The project also provides exposure to multidisciplinary collaborations that bridge fundamental science and translational biomedical research.
How to Apply
Applicants should submit:
- Curriculum Vitae (CV)
- Motivation letter outlining research interests and suitability for the position
- Contact information for two academic or professional referees
- University degree transcripts
Applications must be submitted through the VIB online recruitment system before the deadline.
Application Deadline: 17 July 2026